Migrating colonic crypt epithelial cells: primary targets for transformation.
نویسندگان
چکیده
It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.
منابع مشابه
Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts Running head: Human colonic epithelial stem cells
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ورودعنوان ژورنال:
- Carcinogenesis
دوره 23 11 شماره
صفحات -
تاریخ انتشار 2002